サイトマップENGLISH
山口大学共同獣医学部

教員紹介

生体機能学講座 佐藤 晃一 (SATO Koichi, PhD, DVM)

教授(学部長,評議員)
獣医薬理学分野

k-sato@yamaguchi-u.ac.jp

083-933-5905

研究室のページへ

Reseach Map

担当授業科目

  • 獣医薬理学
  • 毒性学
  • 薬理毒性学実習(分担)
  • 生物機能学実習(分担)
  • 食と生命(分担)

詳細は修学支援システムへ

研究テーマ

  • 消化管粘膜上皮細胞と筋線維芽細胞の微小環境の解明
  • 消化管癌の発生・増悪化におけるがん微小環境の役割解明
  • プロテアーゼ活性化受容体の生理学的,病態生理学的役割の解明
  • 消化管粘膜上皮幹細胞の細胞生物学的研究

主な研究業績

  1. Usui T, Sakurai M, Umata K, et al. Preparation of Human Primary Colon Tissue-Derived Organoid Using Air Liquid Interface Culture. Curr Protoc Toxicol 2018;75:22 6 1-22 6 7.
  2. Usui T, Sakurai M, Umata K, et al. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture. Int J Mol Sci 2018;19.
  3. Enjoji S, Yabe R, Tsuji S, et al. Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis. Mol Cancer Res 2018;16:554-563.
  4. Usui T, Sakurai M, Nishikawa S, et al. Establishment of a dog primary prostate cancer organoid using the urine cancer stem cells. Cancer Sci 2017;108:2383-2392.
  5. Usui T, Sakurai M, Kawasaki H, et al. Establishment of a novel three-dimensional primary culture model for hippocampal neurogenesis. Physiol Rep 2017;5.
  6. Kawasaki H, Saotome T, Usui T, et al. Regulation of intestinal myofibroblasts by KRas-mutated colorectal cancer cells through heparin-binding epidermal growth factor-like growth factor. Oncol Rep 2017;37:3128-3136.
  7. Kake S, Usui T, Ohama T, et al. Death-associated protein kinase 3 controls the tumor progression of A549 cells through ERK MAPK/c-Myc signaling. Oncol Rep 2017;37:1100-1106.
  8. Kake S, Tsuji S, Enjoji S, et al. The role of SET/I2PP2A in canine mammary tumors. Sci Rep 2017;7:4279.
  9. Usui T, Sakurai M, Enjoji S, et al. Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment. Stem Cells Int 2016;2016:7053872.
  10. Tsuji S, Yabe R, Usui T, et al. Anti-tumor effects of perphenazine on canine lymphoma. J Vet Med Sci 2016;78:1293-8.
  11. Fujiwara N, Usui T, Ohama T, et al. Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3). J Biol Chem 2016;291:10858-66.
  12. Yabe R, Miura A, Usui T, et al. Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation. PLoS One 2015;10:e0145226.
  13. Hosoyama T, Samura M, Kudo T, et al. Cardiosphere-derived cell sheet primed with hypoxia improves left ventricular function of chronically infarcted heart. Am J Transl Res 2015;7:2738-51.
  14. Enjoji S, Yabe R, Fujiwara N, et al. The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma. J Vet Med Sci 2015;77:1451-6.
  15. Yabe R, Fujiwara N, Mizuno T, et al. Characterization of SET/I2PP2A Isoforms in Dogs. J Vet Med Sci 2014.
  16. Enjoji S, Ohama T, Sato K. Regulation of Epithelial Cell Tight Junctions by Protease-Activated Receptor 2. J Vet Med Sci 2014.

コンタクトインフォメーション

居室:農学部1階106号室

オフィスアワー:随時