山口大学 共同獣医学部

教員紹介

臨床獣医学講座 水野 拓也 (TAKUYA MIZUNO, PhD, DVM)

教授
獣医臨床獣医学分野

e-mail: mizutaku@yamaguchi-u.ac.jp
Tel: 083-933-5894
Fax: 083-933-5894

個人のページ

担当授業科目

獣医内科学 獣医内科学実習
臨床実習 食と生命(共通教育)

詳細は修学支援システムへ

研究テーマ

・ 犬の腫瘍発生機序の解明
・ 犬の腫瘍に対する新規治療法(抗体療法、低分子化合物、免疫療法、腫瘍溶解ウイルス療法)の開発

主な研究業績

1. Oncolytic reovirus in canine mast cell tumor. Hwang CC, Umeki S, Kubo M, Hayashi T, Shimoda H, Mochizuki M, Maeda K, Baba K, Hiraoka H, Coffey M, Okuda M, Mizuno T. PLoS ONE. in press


2. Function of Feline Signaling Lymphocyte Activation Molecule as a Receptor of Canine Distemper Virus. Hara Y, Suzuki J, Noguchi K, Terada Y, Shimoda H, Mizuno T, Maeda K. J Vet Med Sci. 2013 Mar 26. [Epub ahead of print]


3. Establishment of Five Canine Lymphoma Cell Lines and Tumor Formation in a Xenotransplantation Model. Umeki S, Ema Y, Suzuki R, Kubo M, Hayashi T, Okamura Y, Yamazaki J, Tsujimoto H, Tani K, Hiraoka H, Okuda M, Mizuno T. J Vet Med Sci. 2012 Nov 28. [Epub ahead of print]


4. Anti-adhesive property of P-selectin glycoprotein ligand-1 (PSGL-1) due to steric hindrance effect. Umeki S, Suzuki R, Ema Y, Shimojima M, Nishimura Y, Okuda M, Mizuno T. J Cell Biochem. 2013 Jun;114(6):1271-1285. doi: 10.1002/jcb.24468.


5. A Potential Therapeutic Application of SET/I2PP2A Inhibitor OP449 for Canine T-Cell Lymphoma. Fujiwara N, Kawasaki H, Yabe R, Christensen DJ, Vitek MP, Mizuno T, Sato K, Ohama T. J Vet Med Sci. 2013 Apr 1;75(3):349-54. Epub 2012 Nov 5.


6. Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells. Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada KI, Dörrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii SI. Cancer Res. 2013 Jan 1;73(1):62-73. doi: 10.1158/0008-5472.CAN-12-0759. Epub 2012 Oct 29.


7. Administration of interferon (IFN)-α exacerbates Reovirus type-2-triggered autoimmune insulitis in DBA/1J mice. Nakashima T, Hayashi T, Yamamoto Y, Mizuno T. Scand J Immunol. 2012 Jul 17. doi: 10.1111/j.1365-3083.2012.02754.x. [Epub ahead of print]


8. Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats. Terada Y, Shiozaki Y, Shimoda H, Mahmoud HY, Noguchi K, Nagao Y,

Shimojima M, Iwata H, Mizuno T, Okuda M, Morimoto M, Hayashi T, Tanaka Y, Mochizuki M, Maeda K. J Gen Virol. 2012 Sep;93(Pt 9):1930-4. doi: 10.1099/vir.0.043992-0. Epub 2012 Jun 20.


9. Reovirus type-2 infection in newborn DBA/1J mice reduces the development of late allergic asthma. Nakashima T, Hayashi T, Mizuno T. Int J Exp Pathol. 2012 Jun;93(3):234-42. doi: 10.1111/j.1365-2613.2012.00816.x.


10. Ehrlichia canis Infection in Two Dogs that Emigrated from Endemic Areas. Baba K, Itamoto K, Amimoto A, Kitagawa K, Hiraoka H, Mizuno T, Sato H, Okuda M. J Vet Med Sci. 2012 Jun;74(6):775-8. Epub 2011 Dec 28.


11. Development of High-Grade B-Cell Lymphoma Concurrent with T-Cell Chronic Lymphocytic Leukemia in a Dog. Okawa T, Hiraoka H, Wada Y, Baba K, Itamoto K, Mizuno T, Okuda M. J Vet Med Sci. 2012 May;74(5):677-80. Epub 2011 Dec 27.


12. Destruction of salivary and lacrimal glands by Th1-polarized reaction in a model of secondary Sjogren's syndrome in lupus-prone female NZB x NZWF(1) mice. Hayashi T, Shimoyama N, Mizuno T. Inflammation. 2012 Apr; 35 (2): 638-646.


13. Calreticulin expression in neoplastic versus normal dog mammary glands: A cDNA subtraction-based study. Okawa T, Kurio Y, Morimoto M, Hayashi T, Nakagawa T, Sasaki N, Okuda M, Mizuno T. Res. Vet. Sci. 2012 Feb; 92(1):80-91. Epub 2010 Dec 3.


14. Neutropenia associated with osteomyelitis due to Hepatozoon canis infection in a dog. Shimokawa Miyama T, Umeki S, Baba K, Sada K, Hiraoka H, Endo Y, Inokuma H, Hisasue M, Okuda M, Mizuno T. J Vet Med Sci. 2011 Oct 28;73(10):1389-1393. Epub 2011 Jun 21.


15. Characerization of monoclonal antibodies against canine P-selectin glycoprotein ligand-1 (PSGL-1). Umeki S, Suzuki R, Shimojima M, Ema Y, Yanse T, Iwata H, Okuda M, Mizuno T. Vet. Immunol. Immunopathol. 2011 Jul; 142(1-2):119-125. Epub 2011 Apr 21.


16. Prekallikrein Deficiency in a Dog. Okawa T, Yanase T, Shimokawa Miyama T, Hiraoka H, Baba K, Tani K, Okuda M, Mizuno T. J Vet Med Sci. 2011 Jan;73(1):107-11. Epub 2010 Aug 23.


17. Evaluation of the hemodynamic impact of continuous renal replacement therapy in healthy dogs. Shimokawa Miyama T, Itamoto K, Yoshioka C, Minami K, Okawa T, Fujisaki Y, Hiraoka H, Mizuno T, Okuda M. J Vet Med Sci. 2010 May;72(4):493-497. Epub 2009 Dec 10.


18. Anti-human very late antigen-alpha4 (CD49d) monoclonal antibody (BU49) cross-reacts with the canine B-cell leukemia cell line GL-1, resulting in the induction of homotypic cell aggregation. Ikewaki N, Nakaichi M, Mizuno T, Takamura N, Tokunaga J, Ogata K, Inoko H, Otsu R. Cell Immunol. 2010;263(1):55-64. Epub 2010 Feb 26.


19. Magnetic resornance imaging and clinical findings in a miniature Schnauzer with hypodipsic hypernatremia. Shimokawa Miyama T, Iwamoto E, Umeki S, Nakaichi M, Okuda M, Mizuno T. J Vet Med Sci 2009 Oct;71(10):1387-1391.


20. Crossreactivity of antibodies to canine CD25 and Foxp3 and identification of canine CD4+CD25+Foxp3+ cells in canine peripheral blood. Mizuno T, Suzuki R, Umeki S, Okuda M. J Vet Med Sci 2009 Dec;71(12):1561-1568.


21. Nationwide survey of leptospira antibodies in dogs in Japan: results from microscopic agglutination test and enzyme-linked immunosorbent assay. Iwamoto E, Wada Y, Fujisaki Y, Umeki S, Jones MY, Mizuno T, Itamoto K, Maeda K, Iwata H, Okuda M. J Vet Med Sci. 2009 Sep;71(9):1191-1199.


22. Aberrations of the FHIT gene and Fhit protein in canine lymphoma cell lines. Hiraoka H, Minami K, Kaneko N, Shimokawa Miyama T, Okamura Y, Mizuno T, Okuda M. J Vet Med Sci. 2009 Jun;71(6):769-777.


23. Molecular cloning of the canine fragile histidine triad (FHIT) gene and Fhit protein expression in canine peripheral blood mononuclear cells. Hiraoka H, Minami K, Kaneko N, Shimokawa Miyama T, Mizuno T, Okuda M. J Vet Med Sci. 2009 May;71(5):645-9.


24. Application of polymerase chain reaction to analysis of antigen receptor rearrangements to support endoscopic diagnosis of canine alimentary lymphoma. Kaneko N, Yamamoto Y, Wada Y, Shimokawa Miyama T, Hiraoka H, Itamoto K, Mizuno T, Nakaichi M, Takahashi T, Watari T, Okuda M. J Vet Med Sci. 2009 May;71(5):555-9.


25. Use of formalin-fixed paraffin-embedded tissue and single-strand conformation polymorphism analysis for polymerase chain reaction of antigen receptor rearrangements in dogs. Kaneko N, Tanimoto T, Morimoto M, Hayashi T, Shimokawa Miyama T, Hiraoka H, Itamoto K, Une S, Mizuno T, Okuda M. J Vet Med Sci. 2009 Apr;71(4):535-8.


26. Molecular cloning of canine interleukin-31 and its expression in various tissues. Mizuno T, Kanbayashi S, Okawa T, Maeda S, Okuda M. Vet Immunol Immunopathol. 2009 Sep 15;131(1-2):140-143. Epub 2009 Mar 31.


27. Superficial necrolytic dermatitis associated with extrapancreatic glucagonoma in a dog. Mizuno T, Hiraoka H, Yoshioka C, Takeda Y, Matsukane Y, Shimoyama N, Morimoto M, Hayashi T, Okuda M. Vet Dermatol. 2009 Feb;20(1):72-79.


28. A dog with myelodysplastic syndrome: chronic myelomonocytic leukemia. Hiraoka H, Hisasue M, Nagashima N, Miyama T, Tanimoto T, Watanabe M, Itamoto K, Mizuno T, Inokuma H, Okuda M. J Vet Med Sci. 2007 Jun;69(6):665-8.


29. Cloning of the feline GADD45 cDNA and analysis of its mutation in feline lymphoma cell lines. Oikawa T, Okuda M, Kaneko N, Watanabe M, Hiraoka H, Itamoto K, Nakaichi M, Mizuno T, Inokuma H. J Vet Med Sci. 2006 Mar;68(3):297-301.


30. Experimental inoculation of beagle dogs with Ehrlichia species detected from Ixodes ovatus. Watanabe M, Oikawa T, Hiraoka H, Kaneko N, Itamoto K, Mizuno T, Okuda M, Inokuma H. Vet Parasitol. 2006 Mar 15;136(2):147-54. Epub 2005 Nov 23.

研究内容の紹介

 病気の起こるメカニズムに興味をもっており、分子生物学、細胞生物学、免疫学的手法を用いて研究をおこなっている。現在は、犬の腫瘍(癌)の発生メカニズムと病態解析を行なうことにより、新規治療法(抗体療法、低分子化合物、免疫療法、腫瘍溶解ウイルス療法)を開発し、臨床応用することを目指している。

コンタクトインフォメーション

居室:連合獣医棟301号室

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